Biotechnology and Genetic Engineering
Biotechnology Vol. 7: Drug Discovery
Description
Drug discovery and development is a long term process with involvement of multidisciplinary approach starting from lead identification to pathway analysis to late stage clinical development. A parallel processing of biological, chemical, pharmaceutical and clinical data can provide a solution to the drug discovery puzzle. This volume mainly concentrates on three main sections viz. discovery of lead molecules, updates on antimicrobials and current status of biotherapeutics development, and is hoped to be an essential reading for pharmacologists, medicinal chemists and pharmaceutical scientists working in academia and industry. The following topics have been covered in this volume: • Discovery of novel lead molecules from plant sources • New formulations and applications of natural genistein • Bacterial cell wall as reservoir of novel drug targets • General mechanism of bacterial virulence, role of quorum sensing in determining virulence and biofilm traits in bacteria • Antimicrobial characteristics of Burkholderia produced metabolites • Microbes based therapy for the treatment of cancer • Development and production of natural and synthetic antimicrobial peptides • Regulatory processes for controlling the biosynthesis of Beta-lactam antibiotics in Penicillium chrysogenum and Acremonium chrysogenum fungi • Review of stem cell research in human and veterinary therapeutics • Review on depression and its treatment by new antidepressant molecules • Diuretic effects of urea transporter inhibitors • BCL2 inhibitors for target specific cancer therapy • Trends in development of non-steroidal anti-inflammatory drugs • Review on biological effects of Ecdysteroids and Bisacylhydrazene • Development of novel polyene antifungal formulations • Application of biotechnology in molecular pharmacognosy • Evaluation of toxic risk in drug therapy • Status of biotherapeutics development in India • Best practices followed in biopharmaceutical drug development The volume 7 contains 19 chapters from 51 researchers and/or academicians representing 6 nations, namely China, Egypt, India, Israel, Romania and Spain giving an overview of the various research activities being carried out in different parts of the world in the field of Drug Discovery.
Table of Contents
Foreword to the Series; About the Editors; List of Contributors; About the Series; Preface; Discovery of Novel Lead Molecules from Plant Sources; Natural Compound Genistein: From Consecrated to New Utilizations and Formulations; Bacterial Cell Wall: A Reservoir of Novel Drug Targets; Bacterial Virulence, Biofilm and Quorum Sensing as Promising Targets for Antipathogenic Drug Discovery and the Role of Natural Products; Burkholderia - A Repertoire of Antimicrobial Agents; Microbes as Antitumour Agents: An Emerging Approach for Cancer Therapy; Novel and Synthetic Antimicrobial Peptides: Development and Strategies; Regulatory Processes Controlling the Biosynthesis of Beta-lactam Antibiotics in Penicillium chrysogenum and Acremonium chrysogenum; Stem Cell and Drug Discovery: Novel Approach in Human and Veterinary Therapeutics; Discovery of New Antidepressants by Using Animal Models Along with Various Aspects of Depression; Discovery of Urea Transporter Inhibitors as Novel Diuretics; Targeted Cancer Therapy: The Role of BCL2 Inhibitors; Anti-inflammatory Drugs: Trends in Development of Non-steroidal Anti-inflammatory Drugs NSAIDs; Biological Effects of Ecdysteroids and Their Non-Steroidal Agonist Bisacylhydrazines – A Review; Polyene-Intralipid Formulation Antifungals Against Invasive Mycoses; The Application of Biotechnology in Molecular Pharmacognosy; Evaluation of Toxic Risk in Drug Therapy; Status of Biotherapeutics Development in India; Biopharmaceutical Drug Development Process as the Key in Drug Discovery; Appendix-I: Table of Contents of Biotechnology Series Vols. (1 to 12); Subject Index