Pharmacology
Principles of Experimental Pharmacology
Description
Approach to the experimental pharmacology has been changed in past few years. It is due to the advancement in learning through computer based experimentations. Although it is effective, less expensive and save lives of thousand of experimental animals, understanding and implementation of such kind of knowledge for further study or in industries had certain limitations. Hence, there is a modify in the usual approach of gaining of knowledge, practical skills and developing attitudes in students. A need has, therefore, been felt for a manual that documents why and how a practical should be conducted. This book has fulfilled the need and, in fact, gone beyond merely fulfilling the need. The book has been written keeping in mind the preferred standard shift in the practical curriculum for undergraduate medical students. The chapters in the book have been prepared in sections like in-vivo pharmacology and Ex-vivo pharmacology mainly for clarity and convenience. The book covers all the possible exercises in pharmacology that can be carried out by most institutions, with minimal resources. A useful feature of this book is the sufficient use of diagram, which will help not only the trainee teachers but also the students to understand the mechanism. Each chapter is neatly presented with concision and precision. The objectives of learning are clearly defined, although they could well have been stated at the beginning of the chapter. The clear and relevant illustrations can substitute the lack of materials, which may be the case at some centers. The section on experimental pharmacology describes those experiments that are necessary for the student to understand the fundamental mechanisms of drug action. The author also emphasizes ethics in animal experimentation.
Table of Contents
About the Authors, Preface, To study introduction of experimental pharmacology, To study introduction and basic principles of commonly used laboratory wares for isolated preparations in experimental pharmacology, To study commonly used laboratory animals in experimental pharmacology, To study common routes of drug administration in laboratory animals, To study preparation and purpose of physiological salt solution/drug solution, To study various anesthetic used for laboratory animals, To study different techniques of euthanasia in laboratory animals, To study methods for collection of blood, body fluid and urine in various experimental animals, Introduction to CPCSEA and IAEC guidelines, Screening of drugs on isolated preparations (ex-vivo), Bioassay, To study effect of drugs on ciliary muscle movement in frog, Screening of analgesic drugs (in-vivo), Screening of anti-inflammatory drugs (in-vivo), Screening of drugs acting on CNS (in-vivo), Local anesthetic activity, To study mydriatic and miotic effect of topically applied drugs on rabbit’s eye, To study vasodilator/vasoconstrictor effect of drugs on blood vessels by using perfused rabbit ear (Pissemski method). Diuretic activity, To study effect of hepatic microsomal enzyme inducer inhibitor on the duration of action of Phenobarbital induced sleeping time, To study antipyretic activity by using telethermo- meter method in rats/rabbit, To study anti-secretory and ulcer protective activity in rats by using pylorus ligation technique (SHAY rat model), To study introduction of ED50 and LD50 value, To study introduction of computer assisted learning in pharmacology, References, Subject Index